| 19th Jan - 01h10 |  Shuko Aoyama
Ena Shibahara | def. |  Natela Dzalamidze
Kamilla Rakhimova | 4-6 6-3 6-1 |
| 19th Jan - 01h10 |  Anna-Lena Friedsam
 Ioana Raluca Olaru | def. |  Alizé Cornet
Diane Parry | 6-4 6-4 |
| 19th Jan - 01h10 |  Alexa Guarachi
 Nicole Melichar-Martinez | def. |  Peangtarn Plipuech
 Aldila Sutjiadi | 6-4 6-2 |
| 19th Jan - 01h10 |  Rebecca Peterson
Anastasia Potapova | def. | Irina-Camelia Begu
 Nina Stojanovic | 2-6 6-3 7-5 |
| 19th Jan - 01h10 |  Yi-Fan Xu
Zhaoxuan Yang | def. | Sofia Kenin
 Yulia Putintseva | 7-5 4-6 6-1 |
| 19th Jan - 02h25 | Caroline Garcia
Kristina Mladenovic | def. |  Seone Mendez
Taylah Preston | 6-4 6-2 |
| 19th Jan - 02h45 |  Greet Minnen
Ellen Perez | def. | Jaimee Fourlis
Maddison Inglis | 6-3 6-1 |
| 19th Jan - 02h45 |  Petra Martic
Shelby Rogers | def. | Kaitlyn Christian
 Lidziya Marozava | 6-1 7-6 |
| 19th Jan - 03h05 | Eri Hozumi
Makoto Ninomiya | def. |  Katarzyna Piter
 Mayar Sherif | 6-2 6-4 |
| 19th Jan - 03h15 | Lizette Cabrera
Priscilla Hon | def. |  Leylah Annie Fernandez
 Erin Routliffe | 6-3 6-1 |
| 19th Jan - 05h20 | Danielle Rose Collins
Desirae Krawczyk | def. | Darya Kasatkina
Ludmilla Samsonova | 6-3 6-3 |
| 19th Jan - 05h55 |  Kaja Juvan
Tamara Zidansek | def. |  Nadiia Kichenok
 Sania Mirza | 6-4 7-6 |
| 19th Jan - 06h15 | Samantha Stosur
Shuai Zhang | def. | Miyu Kato
Sabrina Santamaria | 6-3 2-6 6-1 |
| 19th Jan - 06h25 | Caroline Dolehide
Storm Hunter-Sanders | def. |  Anna Karolína Schmiedlová
Kimberley Zimmermann | 6-3 6-2 |
| 19th Jan - 06h40 |  Jasmine Paolini
 Heather Watson | def. | Alexandra Bozovic
Olivia Tjandramulia | 7-6 4-6 6-2 |
| 19th Jan - 06h50 | Anna Danilina
 Beatriz Haddad Maia | def. |  Anna Bondar
 Oksana Kalashnikova | 6-4 6-4 |
| 19th Jan - 07h55 |  Marie Bouzkova
Lucie Hradecka | def. | Irina Maria Bara
Ekaterine Gorgodze | 6-3 6-4 |
| 20th Jan - 01h05 | Kimberly Birrell
Charlotte Kempenaers-Pocz | def. |  Nuria Parrizas Diaz
 Arantxa Rus | 6-3 2-6 6-4 |
| 20th Jan - 01h10 | Viktória Kuzmová Hruncáková
Vera Zvonareva | def. | Varvara Gracheva
Anhelina Kalinina | 6-2 6-4 |
| 20th Jan - 01h10 | Nao Hibino
Alicja Rosolska | def. | Ann Li
Alison Riske-Amritraj | 3-6 7-6 6-4 |
| 20th Jan - 01h10 | Marta Kostyuk
Dayana Yastremska | def. | Cori Gauff
Caty McNally | 5-7 6-4 7-5 |
| 20th Jan - 03h25 | Gabriela Dabrowski
 Giuliana Olmos | def. | Clara Burel
 Maria Camila Osorio Serrano | 6-2 6-3 |
| 20th Jan - 03h50 | Lyudmyla Kichenok
 Jelena Ostapenko | def. |  Viktorija Golubic
Jil Belen Teichmann | 6-3 6-1 |
| 20th Jan - 04h10 | Kirsten Flipkens
Sara Sorribes Tormo | def. | Julia Lohoff-Wachaczyk
Maryna Zanevska | 7-5 6-4 |
| 20th Jan - 04h45 | Monique Adamczak
Xinyun Han | def. | Madison Brengle
Tatjana Maria | 6-4 6-7 6-3 |
| 20th Jan - 05h45 | Barbora Krejcikova
Katerina Siniaková | def. | Lesley Pattinama Kerkhove
Arina Rodionova | 6-0 6-2 |
| 20th Jan - 06h15 | Aliona Bolsova Zadoinov
 Ulrikke Eikeri | def. | Elixane Lechemia
Ingrid Neel | 6-4 3-6 6-2 |
| 20th Jan - 06h15 | Tereza Martincova
Marketa Vondrousova | def. | Darija Jurak
Andreja Klepac | 6-4 6-3 |
| 20th Jan - 07h05 | Veronika Kudermetova
Elise Mertens | def. | Anna Blinkova
Aliaksandra Sasnovich | 6-7 6-3 6-3 |
| 20th Jan - 07h45 | Magda Linette
Bernarda Pera | def. |  Clara Tauson
Alison Van Uytvanck | 6-2 2-6 6-0 |
| 21th Jan - 05h15 | Jaqueline Adina Cristian
Andrea Petkovic | def. | Simona Halep
Elena Gabriela Ruse | 6-4 6-0 |
| 21th Jan - 05h45 | Asia Muhammad
Jessica Pegula | def. |  Danka Kovinic
Aleksandra Krunic | 6-1 6-1 |
